Selected publications
Karaman S, Buschle D, Luciani P, Leroux JC, Detmar M, Proulx ST:
Decline of lymphatic vessel density and function in murine skin during aging.
Angiogenesis. 2015 Aug 11. [Epub ahead of print].
Bianchi R, Teijeira A, Proulx ST, Christiansen AJ, Seidel CD, Rülicke T, Mäkinen T, Hägerling R, Halin C, Detmar M:
A transgenic Prox1-Cre-tdTomato reporter mouse for lymphatic vessel research.
PLoS One. 2015 Apr 7;10(4):e0122976.
Karaman S, Hollmen M, Robciuc MR, Alitalo A, Nurmi H, Morf B, Buschle D, Alkan HF, Ochsenbein AM, Alitalo K, Wolfrum C, Detmar M:
Blockade of VEGF-C and VEGF-D modulates adipose tissue inflammation and improves metabolic parameters under high-fat diet.
Mol Metab. 2014 Dec 4;4(2):93-105.
Bianchi R, Fischer E, Yuen D, Ernst E, Ochsenbein AM, Chen L, Otto VI, Detmar M:
Mutation of threonine 34 in mouse podoplanin-Fc reduces CLEC-2 binding and toxicity in vivo while retaining antilymphangiogenic activity.
J Biol Chem. 2014 Jul 25;289(30):21016-27.
Zheng W, Nurmi H, Appak S, Sabine A, Bovay E, Korhonen EA, Orsenigo F, Lohela M, D'Amico G, Holopainen T, Leow CC, Dejana E, Petrova TV, Augustin HG and Alitalo K:
Angiopoietin 2 regulates the transformation and integrity of lymphatic endothelial cell junctions.
Genes Dev, 28:1592-603, 2014.
Blum S*, Karaman S*, Proulx ST, Ochsenbein AM, Luciani P, Leroux JC, Wolfrum C, Detmar M.
Chronic high-fat diet impairs collecting lymphatic vessel function in mice.
PLOS ONE, 2014 Apr 8;9(4):e94713. *equally contributing authors.
Karaman S, Detmar M:
Mechanisms of lymphatic metastasis.
J Clin Invest 2014; 124: 922-928.
Hirakawa S, Detmar M, Karaman S:
Lymphatics in nanophysiology.
Adv Drug Deliv Rev 2014 Feb 10. 74:12-8.
Ochsenbein AM*, Karaman S*, Jurisic G, Detmar M:
The role of neuropilin1/ semaphorin 3A signaling in lymphatic vessel development and maturation.
Adv Anat Embryol Cell Biol 2014; 214: 143-152. *equally contributing authors.
Valcheva N, Primorac A, Jurisic G, Hollmen M, Detmar M:
The orphan adhesion G protein-coupled receptor GPR97 regulates migration of lymphatic endothelial cells via the small GTPases RhoA and Cdc42.
J Biol Chem 2013; 288: 35736-35748.
Rutkowski JM, Markhus CE, Gyenge CC, Alitalo K, Wiig H, Swartz MA:
Dermal collagen and lipid deposition correlate with tissue swelling and hydraulic conductivity in murine primary lymphedema.
Am J Pathol 2010; 176:1122-29.
Nykänen AI, Sandelin H, Krebs R, Keränen MA, Tuuminen R, Kärpänen T, Wu Y, Pytowski B, Koskinen PK, Ylä-Herttuala S, Alitalo K, Lemström KB:
Targeting lymphatic vessel activation and CCL21 production by VEGFR-3 inhibition has novel immunomodulatory and antiarteriosclerotic effects in cardiac allografts.
Circulation 2010;121:1413-22.
Augustin HG, Koh GY, Thurston G, Alitalo K:
Control of vascular morphogenesis and homeostasis through the angio-poietin-Tie system.
Nat Rev Mol Cell Biol 2009;10:165-77.
Goettsch W, Gryczka C, Korff T, Ernst E, Goettsch C, Seebach J, Schnittler HJ, Augustin HG, Morawietz H:
Flow-dependent regulation of angiopoietin-2.
J Cell Physiol 2008;214:491-503.
Johnson NC, Dillard ME, Baluk P, McDonald DM, Harvey NL, Frase SL, Oliver G:
Lymphatic endothelial cell identity is reversible and its maintenance requires Prox1 activity.
Genes Dev 2008;22:3282-91.
Lohela M, Heloterä H, Haiko P, Dumont DJ, Alitalo K:
Transgenic induction of vascular endothelial growth factor-C is strongly angiogenic in mouse embryos but leads to persistent lymphatic hyperplasia in adult tissues.
Am J Pathol 2008;173:1891-901.
Baluk P, lt Fuxe J, Hashizume H, Romano T, Lashnits E, Butz S, Vestweber D, Corada M, Molendini C, Dejana E, McDonald DM:
Functionally specialized junctions betweenendothelial cells of lymphatic vessels.
J Exp Med 2007;204:2349-62.
Fiedler U , Reiss Y , Scharpfenecker M , Grunow V , Koidl S , Thurston G , Gale NW , Witzenrath M , Rosseau S , Suttorp N , Sobke A , Herrmann M , Preissner KT , Vajkoczy P , Augustin HG:
Angiopoietin-2 sensitizes endothelial cells to TNF- alpha and has a crucial role in the induction of inflammation.
Nat Med 2006;12:235-39.
Harvey NL , Srinivasan RS , Dillard ME , Johnson NC , Witte MH , Boyd K , Sleeman MW , Oliver G:
Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity.
Nat Genet 2005;37:1072-81.
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